THE EVOLUTION OF INSOMNIA DRUG THERAPY: BARBITURATES
Friday, December 17th, 2010The use of barbiturates for sleep has all but disappeared in recent years. In 1971 these drugs accounted for 47 percent of the prescriptions for hypnotic medications; six years later the figure had dropped to 17 percent, and by 1982 it was 9 percent. That the figure is even this high has more to do with entrenched prescribing habits among some physicians than with appropriate choice of therapy. One reason for the decline is the high risk of tolerance, dependence, and addiction involved with the use of barbiturates. Besides, such drugs as Seconal and Nembutal lose their effectiveness quickly, compelling users to step up the dosage.
Barbiturates can be deadly drugs; a dosage only fifteen times higher than that needed for sleep can be fatal. In the past barbiturates were the drugs most frequently used in suicide attempts. The presence of alcohol greatly increases the danger; even relatively small doses of barbiturates and alcohol can be fatal. Furthermore, the liver deterioration that accompanies alcoholism means that heavy drinkers are at special risk if they also use barbiturates because these toxic drugs must be broken down in the liver. These drugs may actually worsen sleep by suppressing the deep NREM and REM stages. And during withdrawal from medication, sleep can be even worse than before use of the drug and is marked by REM rebound, hallucinations, anxiety, or, in severe cases, seizures.
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